COMPREHENSIVE ANALYSIS OF H3K27ME3 LOCKS UNDER DIFFERENT DNA METHYLATION CONTEXTS REVEAL EPIGENETIC REDISTRIBUTION IN TUMORIGENESIS

Comprehensive analysis of H3K27me3 LOCKs under different DNA methylation contexts reveal epigenetic redistribution in tumorigenesis

Abstract Background Histone modification H3K27me3 plays a critical role in normal development and is associated with various diseases, including cancer.This modification forms large chromatin domains, known as Large Organized Chromatin Lysine Domains (LOCKs), which span several hundred kilobases.Result In this study, we identify and categorize H3K2

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